Intraepithelial carcinoma (Bowen disease) - Carcinoma Intraepiteliale (Malattia Di Bowen)
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Casu tipicu ― Carcinoma Intraepiteliale (Malattia Di Bowen) (Intraepithelial carcinoma (Bowen disease)) pò esse misdiagnosed cum'è un eczema di longa durata, senza prurito.
References
Bowen's disease (BD) hè un tipu di cancru di a pelle chì principia in a capa esterna di a pelle (epidermis) . Hè più cumuni in i Caucasiani è spessu si trova in i zoni esposti à a luz di u sole, ma pò esse ancu in altrò. BD tipicamente si mostra cum'è una sola lesione. BD hè spessu vistu cum'è un signu d'avvertimentu prima chì un tipu più seriu di cancru di a pelle si sviluppa. Per diagnosticà BD, i medichi di solitu si basanu nantu à esaminà mostre di tissuti sottu un microscopiu (biopsia) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease affetta soprattuttu individui bianchi di più di 60 anni. I fatturi di risichi chjave includenu l'esposizione à u sole longu, u sistema immune debilitatu, l'esposizione à l'arsenicu è l'infezzione di a pelle HPV. I ceppi di HPV 16, 18, 34 è 48 sò ligati à a malatia di Bowen in i zoni genitali. L'implicazione di HPV in i casi non-genitali hè menu chjaru.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Di solitu appare cum'è una zona eritematosa, squamosa o crosta in ogni locu di u corpu. U locu più cumuni hè a gammi più bassu.
Hè curabile da diverse opzioni di trattamentu cum'è crioterapia, curettage, cauterizzazione, terapia fotodinamica, o excisione di a lesione.
○ Diagnosi è Trattamentu
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy